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Review Article
Obesity and Metabolism
Genetic and Environmental Factors Contributing to Visceral Adiposity in Asian Populations
Rachel Williams, Muthu Periasamy
Endocrinol Metab. 2020;35(4):681-695.   Published online December 23, 2020
DOI: https://doi.org/10.3803/EnM.2020.772
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  • 27 Web of Science
  • 29 Crossref
AbstractAbstract PDFPubReader   ePub   
Obesity-associated metabolic illnesses are increasing at an alarming rate in Asian countries. A common feature observed in the Asian population is a higher incidence of abdominal obesity—the “skinny-fat” Asian syndrome. In this review, we critically evaluate the relative roles of genetics and environmental factors on fat distribution in Asian populations. While there is an upward trend in obesity among most Asian countries, it appears particularly conspicuous in Malaysia. We propose a novel theory, the Malaysian gene-environment multiplier hypothesis, which explains how ancestral variations in feast-and-famine cycles contribute to inherited genetic predispositions that, when acted on by modern-day stressors—most notably, urbanization, westernization, lifestyle changes, dietary transitions, cultural pressures, and stress—contribute to increased visceral adiposity in Asian populations. At present, the major determinants contributing to visceral adiposity in Asians are far from conclusive, but we seek to highlight critical areas for further research.

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